Influenza Virus and Macrophage
Influenza A Infection in Macrophages
This diagram is a Petri Net model detailing the molecular interactions involved in the Influenza A Virus Infection of a Macrophage.
Our model represents a single cell exposed to 10 virions of H1N1 Influenza A Virus for 6 minutes. This condition is simulated by introducing 10 input tokens, considered equivalent to 10 virions, for 2 time blocks (1 time block = 3 min).
In these conditions the expected viral progeny from a single inflammatory monocyte or non-primed macrophage is ~4E3 virions.
The dynamic accumulation of tokens in the model can be visualized using the simulation tool of Graphia Professional. The simulation is performed using a standard normal distribution of tokens, for 500 runs and 100 time blocks, which are equivalent to 5 hours of infection.